Patent for License:

Fluorescent nanodiamonds    

The material is chemically stable and has low cytotoxicity, and its surface can be easily derivatized with functional groups for specific biomolecular targeting or tumor targeting.

Overview

Currently, this invention is the only one in the world capable of producing nanodiamonds with strong fluorescence.
The nanodiamonds emit bright fluorescence at 550 � 800 nm, well suited for biological applications such as cellular imaging. The emission shows no signs of photobleaching and blinking under high-power laser excitation. The material is chemically stable and has low cytotoxicity, and its surface can be easily derivatized with functional groups for specific biomolecular targeting or tumor targeting. An experiment on single-particle tracking of the fluorescent nanodiamond in a live cell was successfully performed, demonstrating the superb photophysical and biochemical properties of the novel nanomaterial.

Primary Application of the Technology

Biomedical science & biotechnology
Biomolecular labeling

Other Potential Applications

(1) Cellular imaging
(2) Tumor targeting
(3) Single particle tracking
(4) Medicinal drug delivery
(5) Gene therapy carrier

Competitive Advantage

(1) Low cost, easy to use
(2) Highly stable, no shelf lifetime
(3) Chemically inert, environmentally safe
(4) High fluorescence brightness, comparable to that of quantum dots
(5) No photobleaching and no fluorescence intermittency (blinking)
(6) Long penetration depth of fluorescence through tissue
(7) Low cytotoxicity and low human toxicity
(8) Easy surface functionalization and modification
(9) Capable of multicolor emission
(10) Capable of multiphoton imaging

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 435: Chemistry: Molecular Biology And Microbiology

This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.

Subclass 173.1: TREATMENT OF MICRO-ORGANISMS OR ENZYMES WITH ELECTRICAL OR WAVE ENERGY (E.G., MAGNETISM, SONIC WAVES, ETC.)

Class 204: Chemistry: Electrical And Wave Energy

This class includes, where not provided for elsewhere: A. Processes (1) involving the use of electrolysis (as provided for in Class 205); (2) of preparing or purifying compounds or elements involving chemical reaction brought about by electrical or wave energy in a magnetic field; (3) of treating materials involving chemical reaction brought about by wave energy; (4) of preparing or purifying compounds or elements involving chemical reaction brought about by an electrostatic field or electrical discharge; (5) involving the use of electrophoresis or electro-osmosis; (6) of treating a liquid (a) to separate or purify the liquid using electric and magnetic fields simultaneously, (b) to separate or purify the liquid using an electric field, or (c) using a magnetic field to obtain some effect other than mere separation or purification of the liquid; (7) involving coating, forming, or etching by the use of sputtering; and (8) involving coating by the use of vacuum arc discharge.

Subclass 157.44: Using ionizing radiation

Class 250: Radiant Energy

This class provides for all methods and apparatus for using, generating, controlling or detecting radiant energy, combinations including such methods or apparatus, subcombinations of same and accessories therefore not classifiable elsewhere.

Subclass 433: Including a movable surface transfer means

Class 252: Compositions

(A) Compositions of matter, having or not having structure, physical form or heterogeneous arrangement of components and for which there is no provision elsewhere. (B) Packages of such compositions, or other articles which include such compositions for which there is no provision elsewhere. (C) Processes of making, or peculiar to making, such compositions and for which there is no provision elsewhere. (D) Apparatus for use in or peculiar to such processes and for which there is no provision elsewhere.

Subclass 301.4R: INORGANIC LUMINESCENT COMPOSITIONS
Subclass 301.4F: Group IV element containing

Class 428: Stock Material Or Miscellaneous Articles

This is the residual class for: 1. Stock material in the form of a structurally defined web, sheet, rod, strand, fiber, filament, cell, flake, particle not provided elsewhere. 2. Stock material in the form of a web, sheet, mass or layer which consists of or contains a structurally defined constituent or element. 3. A nonstructural laminate defined merely in terms of the composition of one or more layers. 4. An article of manufacture or an intermediate-article not provided for elsewhere. 5. A process for applying an impregnating material to a naturally solid product such as a wood beam, a sheet of leather or a stone, or for applying a coating to a base, and which process includes no significant method step.

Subclass 402: Particulate matter (e.g., sphere, flake, etc.)