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Patent for Sale:

Advanced Resin Technology (ART) - Drug Delivery System    

11 patents issued worldwide and 17 patents pending make up 5 patent families.

Overview

A resin based drug delivery system that promotes transmucosal and topical delivery of medications more efficiently and effectively than currently known technologies.

The advantage of the patented transmucosal technology is that with a tiny drop placed on the inside of the cheek, medications can be delivered into the bloodstream reaching a maximum concentration on the order of minutes - much more quickly than with transdermal patches and pills, and even more quickly than inhalers and nasal sprays that are specifically designed for quick delivery of medications. Clinical trial results confirm not only quick delivery but safe and prolonged delivery of medications. The mechanism of action has been delineated in the laboratory on a molecular level.

The seller is engaged primarily in the research and development of its patented resin, trans-mucosal systemic delivery of active ingredients focused on the Central Nervous System (“CNS”) market place. The current formulations are designed to provide quick delivery of vardenafil for erectile dysfunction, alprazolam for anxiety, ondansetron for nausea, sumitriptan for migraines, fentanyl for pain, and nicotine as an aid to smoking cessation.

The patent seller has two market ready products. They have successfully completed pre-clnical and phase 1 clinical tests on a stable transmucosal Nicotine Replacement Therapy (NRT) product that outperforms current products on the market. This product is ready for market launch in the $2.5B NRT marketplace. Trial batches have been manufactured, and test marketing resulted in overnight success with the trial batch being sold-out and retailed in over 100 stores.

The seller's patented resin technology also safely keeps 100% of an active ingredient in place on the skin, while providing a controlled but increased rate of release of the active ingredient into the skin over a sustained period of time. As a result, they have consistently demonstrated that its topical formulations out-perform market leaders in many product categories.

The seller has achieved FDA exemption on a topical, post-operative surgical adhesive product that is impregnated with the antibiotic bacitracin. The product secures bandages to post-operative wounds while protecting against bacterial contamination. The data profile on this product shows superiority over the surgical adhesive without antibiotic. The patent family covering this product generates license revenues and has been licensed exclusively in the U.S., but international markets are open.

The patent seller additionally has two clinical stage topical products. The first is a topical surgical prep product with phase 1 and 2 clinical trial data. This product adheres to drapes and has a superior bacterial log-reduction profile over time compared to current products on the market. The surgical prep arena is $2B worldwide. The seller has additionally completed phase 1 testing on a Topical Diclofenac product with pre-clinical results that show superiority over current marketplace products, and a phase 1 clinical trial that indicates statistical superiority over placebo.

The seller has worked to develop and license a deep pipeline of drug products focused on large markets in the CNS sector. The products developed by the seller for subsequent distribution by potential licensees in the U.S. have relatively short time-to-market regulatory pathways with the FDA.

Primary Application of the Technology

Pharmaceutical Industry - Nicotine Replacement Therapy; Topical Surgical Prep products; Topical Pain Relief for acute injuries, Arthritis, Migraines, Anxiety and more

The Problem Solved by the Technology

The problem solved by Advanced Resin Technology is that many medications take too long to act, and when they do achieve efficacy, they only do so for a short period of time. Advanced Resin Technology (ART) is the art and science of combining particular resins from trees around the world with specific medications, and in the process of doing so the medications are made much more powerful. The medications are potentiated and act more quickly and for a significantly longer period of time.

How the Technology Solves the Problem

ART works in two phases. In phase 1, it immediately but safely loads cells with the active ingredient. In phase two, it forms a reservoir on the skin or mucosa that contains the medication, and the medication is released from the reservoir in a controlled and sustained fashion over time.

Competitive Advantage

The effects of Resin Drug Delivery are:

1. Very Fast Onset
2. Prolonged Relief
3. Safe

The seller may consider selling these patents individually.

Frequently Asked Questions

Is the technology safe? We have conducted human safety trials proving its safety.

Do you have clinical data? Yes, we have conducted a number of phase 1 and 2 trials to determine efficacy and safety.

Are there sales? Our first product will be commercially distributed in North America.

What are the regulatory issues? We have regulatory feedback from the FDA and the MHRA regarding our mature clinical stage products.

Additional Information

The patent seller has two market ready products and two clinical stage products developed.

One patent family generates license revenues and has been licensed exclusively in the U.S., international markets are open.

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 424: Drug, Bio-Affecting And Body Treating Compositions

This class includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.

Subclass 443: Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments
Subclass 446: Medicated gauze pads
Subclass 448: Pressure sensitive adhesive means
Subclass 449: Transdermal or percutaneous
Subclass 485: Natural gums, resin or latex
Subclass 496: Containing natural gums/resins
Subclass 48: CHEWING GUM TYPE
Subclass 49: DENTIFRICES (INCLUDES MOUTH WASH)
Subclass 59: TOPICAL SUN OR RADIATION SCREENING, OR TANNING PREPARATIONS
Subclass 60: Aromatic acid or derivative containing (e.g., aminobenzoic acid or methyl salicylate, etc.)
Subclass 78.03: Skin cosmetic coating
Subclass 78.05: Anti-inflammatory or anti-irritant (e.g., anti-arthritic, etc.)
Subclass 78.06: Skin burn or open wound treatment
Subclass 78.07: Anti-infective
Subclass 195.18: NATURAL RESIN, GUM, OR BALSAM AS ACTIVE INGREDIENT (E.G., CONIFER RESIN, PINE GUM, ROSIN, NATURAL LATEX, ETC.)

Class 514: Drug, Bio-Affecting And Body Treating Compositions

This class is an integral part of Class 424. It includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.

Subclass 27: Oxygen of the saccharide radical bonded directly to a nonsaccharide hetero ring or a polycyclo ring system which contains a nonsaccharide hetero ring
Subclass 159: Ortho-hydroxybenzoic acid (i.e., salicyclic acid) or derivative DOAI
Subclass 178: Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system
Subclass 184: Heavy metal containing (including salts)
Subclass 220: Tricyclo ring system having the seven-membered hetero ring as one of the cyclos
Subclass 230.5: Bicyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,4-benzoxazines, etc.)
Subclass 243: Polycyclo ring system having the hetero ring as one of the cyclos
Subclass 254.07: Chalcogen hetero ring attached directly or indirectly to the piperazine ring by nonionic bonding
Subclass 262.1: Exactly four ring nitrogens in the bicyclo ring system
Subclass 290: Tricyclo ring system having the six-membered hetero ring as one of the cyclos
Subclass 343: The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.)
Subclass 345: Chalcogen bonded directly to ring carbon of the six-membered hetero ring
Subclass 376: Chalcogen bonded directly to ring carbon of the oxazole ring
Subclass 396: Imidazoles
Subclass 397: Additional hetero ring
Subclass 413: Ring nitrogen is shared by the cyclos of the bicyclo ring system
Subclass 509: (O=)N(=O)-O-C containing (e.g., nitrate ester, etc.)
Subclass 532: Z-C(=O)-O-Y, wherein Z contains a benzene ring
Subclass 568: Benzene ring nonionically bonded
Subclass 655: The aryl ring or aryl ring system and amino nitrogen are bonded directly to the same acylic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto
Subclass 772.3: Solid synthetic organic polymer
Subclass 782: Natural gum or resin

Class 106: Compositions: Coating Or Plastic

This class is the broad generic class for: (1) Coating, impregnating or plastic compositions, especially those which set or harden to retain a given shape. Most of the compositions herein found are those which are capable of undergoing a change from a fluent to a nonfluent condition, or from a solid noncoherent form to a solid coherent form. (2) Materials or ingredients, not in themselves coating, for use in such compositions and for which there is no provision elsewhere. (3) This class takes processes for preparing or making the compositions, materials, or ingredients classified herein, which processes are classified with the corresponding composition, material or ingredient. (4) This class does not include patents which are limited to apparatus only.

Subclass 218: Natural resin or derivative containing
Subclass 237: Alcohol containing

Class 433: Dentistry

This class is a specific class under the broader class of Surgery and includes methods directed to or including specific dental steps, e.g., taking impressions of the teeth or gums, adapting a plate or model to a particular mouth formation, mounting teeth on a plate in a particular way, etc.; apparatus, implements, and devices relating to the treatment of teeth or gums, or the replacement of teeth.

Subclass 217.1: By lining or coating
Subclass 35: Having cooling means