Patent for Sale:Therapeutic for the Prevention and Treatment of Alzheimer's Disease and other Neurological Disorders
Primary Application of the Technology
The Problem Solved by the Technology
How the Technology Solves the Problem
Over half of US National Institute of Health funded AD research is directed at plaque formation. In 2005, evidence was obtained that beta amyloid protein fragments were initi-ative rather than symptomatic. Scientists have now shown that a two-molecule aggregate of beta-amyloid protein fragments may play a role in initiating the disease. Current AD research is being redirected to either secretase inhibition or beta amyloid reduction.
1. Hypothesis 1.
Abnormal processing of amyloid precursor protein (APP) yields beta amyloid protein resulting in amyloid plaques.
a. Strategy: Destroy beta amyloid
b. Strategy: Target secretase which cuts APP into beta amyloid
2. Hypothesis 2.
Tau protein which supports cell structure, deforms and aggregates into neurofibrillary tangles.
a. Strategy: Target phosphorylation of tau
In contrast, rather than inhibiting and reducing these causal factors, our therapeutic has been designed to prevent their initial formation. The molecule upon which it is based has been shown to both inhibit abnormal processing of APP and hyper-phosphorylation of tau protein and inhibits TNF alpha.
It has recently been recognized that there is a link between diabetes and AD. We independently discovered the link between insulin, carbohydrate metabolism, and AD and termed the group of related diseases Metabolic Disorder Syndrome. This discovery led to the understanding that our therapeutic could address the causative agent of Metabolic Disorder Syndrome by attacking the syndrome at a cascade point in the metabolism.
Class 514: Drug, Bio-Affecting And Body Treating Compositions
This class is an integral part of Class 424. It includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.Subclass 455: Chalcogen bonded directly to ring carbon of the hetero ring
Subclass 456: Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)