Patent for Sale:

Advanced Composite Material    

This material is composed of a substratum of reticulated foam to which is grafted a unique hydrogel polymer.

Overview

This material is composed of a substratum of reticulated foam to which is grafted a unique hydrogel polymer. Based on the science of hydrophilic polyurethane (HPUR), the composite combines the unique properties of HPUR on a reticulate polyurethane scaffold. The result is a low-pressure drop, high internal surface area, and high void volume architecture with a hydrophilic, chemically active surface. This surface can be a reservoir for active ingredients, a biocompatible surface for cell growth, or a convenient system for the immobilization of active molecules, including enzymes.

This portfolio discloses a material relevant to a variety of technology areas, including advanced medical systems, environmental remediation, and consumer products. While the material as described has many applications, especially in household and personal care products, the true value of the material is in the potential to modify the hydrophilic surface, chemically and physically, including applications for advancements in medical systems and environmental remediation.

Advanced Medical Systems – Pharmaceutical and biotech companies spend approximately $60 billion annually on R&D. Each new drug costs close to $1 billion to develop and market. Part of the high cost is due to the fact that 50-60% of drugs that pass preclinical testing fail in humans. The reason for this is human metabolism and toxicity are difficult to predictin the lab. Traditionally, test methods culture liver cells on two-dimensional surfaces. In such environments, the cells are forced to adopt unnatural flattened morphologies. This is thought to result in false positives in 40-50% of tests.

There is a strong demand for new cell culture platforms that allow cells to grow more naturally. It is widely acknowledged that three-dimensional cell growth is likely to more accurately reflect the natural tissue environments.

The patent portfolio describes a composite material that shows promise as such a material. It is composed of an open-cell foam architecture to which is grafted a biocompatible hydrogel surface. The result is a flow-through device with a coating appropriate for cell growth. Additionally, cell attachment molecules can conveniently be bonded to the hydrogel surface.

Environmental Remediation – The use of bacteria to treat organic pollutants is well documented. The same properties that make it attractive as a substratum for liver cells make it ideal for colonization by waste water degrading bacteria and other remediation organisms. The hydrogel surface is an excellent environment for colonization by bacteria, and the open architecture provides for superior flow-through properties, high surface area, and high void volume, all desirable properties for an engineering material.

Additionally, the composite has the ability to extract polar organic pollutants from water and air. Still further, the material is conveniently reactive with enzymes for the treatment of difficult pollutants.

Primary Application of the Technology

Important portfolio for pharmaceutical, medical device, environmental engineering, and consumer product companies

The Problem Solved by the Technology

The technology was developed as an improvement of a commercial polyurethane.

Competitive Advantage

The material has certain advantages of current materials used for cell propagation for medical and environmental remediation.

The enhanced properties give it properties unmatched by the original polyurethane. Specifically the open architecture increases surface area and mass transport properties of the polymer foam.

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 428: Stock Material Or Miscellaneous Articles

This is the residual class for: 1. Stock material in the form of a structurally defined web, sheet, rod, strand, fiber, filament, cell, flake, particle not provided elsewhere. 2. Stock material in the form of a web, sheet, mass or layer which consists of or contains a structurally defined constituent or element. 3. A nonstructural laminate defined merely in terms of the composition of one or more layers. 4. An article of manufacture or an intermediate-article not provided for elsewhere. 5. A process for applying an impregnating material to a naturally solid product such as a wood beam, a sheet of leather or a stone, or for applying a coating to a base, and which process includes no significant method step.

Subclass 304.4: Composite having voids in a component (e.g., porous, cellular, etc.)
Subclass 305.5: With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
Subclass 306.6: Void-containing component partially impregnated with adjacent component
Subclass 308.4: Void-containing component is synthetic resin or natural rubbers
Subclass 309.9: With internal element bridging layers, nonplanar interface between layers, or intermediate layer of commingled adjacent foam layers
Subclass 315.7: Specified thickness of void-containing component (absolute or relative) or numerical cell dimension
Subclass 316.6: Plural void-containing components
Subclass 317.9: Void-containing component contains also a solid fiber or solid particle
Subclass 319.3: Synthetic resin or natural rubbers

Class 427: Coating Processes

This is the generic class for: A. applying or obtaining a coating on a surface. The coating may be hard or soft, permanent or transitory, supplied solely by extraneous materials or supplied wholly or in part by the base material. B. impregnating a base by causing a coating material to extend or penetrate into the base material, or into the interstices of a porous, cellular or foraminous material. C. taking preparatory treatments of the base material, subsequent treatments of the coated base material and other ancillary noncoating operations claimed, per se, processes limited to etching for making a base more compatible with, or adherent to, the coating wherein the base is the substrate (work) onto which a coating is applied are included.

Subclass 243: FORAMINOUS PRODUCT PRODUCED
Subclass 244: Filter, sponge, or foam
Subclass 373: Cells, foam, or bubbles formed