Patent for License with Right to Enforce:

Regulation of Apotosis in Aquatic Organisms by Aquabirnvirus    

It discloses a new IPNV infection mechanism in aquatic animal.

Overview

The technology relates to apoptosis in aquatic organisms induced by aquabirnavirus, preferably infectious pancreatic necrosis virus (IPNV). It also relates to technique to regulate apoptosis in aquatic cells by controlling the expression of Mcl-1 gene and pre-treating the aquatic cells with drugs that block the viral replication. Plus a technique for monitoring the progress of apoptosis using EGFP as a probe and providing a new strategy for fish disease prevention

Primary Application of the Technology

1. Providing a mechanism of apoptosis in aquatic organism for studies of apoptosis in aquatic organisms.

2. Providing a inducible and inhibitive model for apoptosis.

3. Avoiding the invasion of virus to economical aquatic organisms and developing a new antiviral method.

The Problem Solved by the Technology

Not a clear mechanism relating to IPNV induced apotosis has been discussed before.

Competitive Advantage

1. The technology of EGFP can measure the morphology of apoptosis more precisely comparing with traditional methods.

2. By studying the mechanism of virus-infected apoptosis can be used for blocking the virus replication.

The seller would like to be granted a license back.

The seller may consider selling these patents individually.

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 514: Drug, Bio-Affecting And Body Treating Compositions

This class is an integral part of Class 424. It includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.


Class 435: Chemistry: Molecular Biology And Microbiology

This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.

Subclass 5: Involving virus or bacteriophage
Subclass 235.1: VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATING
Subclass 325: ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE

Class 536: Organic Compounds -- Part Of The Class 532 Series

The classes of the 532 series embrace monomeric organic carbon compounds and polymeric organic carbon compounds that are not solid synthetic resins, natural rubbers, or hydrocarbons.

Subclass 23.1: DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)
Subclass 23.2: Encodes an enzyme
Subclass 23.4: Encodes a fusion protein

Class 800: Multicellular Living Organisms And Unmodified Parts Thereof And Related Processes

This is the class for living multicellular organisms (nonhuman animals and plants) and separated or severed parts thereof that have not undergone any modification or treatment subsequent to their separation. These organisms or parts thereof may be genetically modified. This class also includes processes of producing said multicellular organisms and of using said organisms (nonhuman animals) in testing and protein production processes. This class provides for the following products: living multicellular organisms, living products, separated or severed parts of multicellular plants and transgenic nonhuman animals which have not been modified or treated subsequent to their separation. This class provides for the following processes: methods of plant breeding; methods of mutating plants; methods of producing plants using somatic cell fusion; and methods of introducing nucleic acid into or rearrangement of genetic material within a plant. All of these methods result in a living plant or plant part.

Subclass 285: The polynucleotide encodes an inhibitory RNA molecule
Subclass 286: The RNA is antisense

Class 424: Drug, Bio-Affecting And Body Treating Compositions

This class includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.

Subclass 93.1: WHOLE LIVE MICRO-ORGANISM, CELL, OR VIRUS CONTAINING

Class 119: Animal Husbandry

Methods or apparatus for the propagation, rearing, training, exercising, amusing, feeding, milking, grooming, housing, controlling, handling, or general care of a living animal unless provided for elsewhere.

Subclass 210: With feeding
Subclass 215: Fish culturing