Tynax ~ Patent Library

Patent for Sale:

Method and Diagnostic Kit for Diagnosing Susceptibility of Post-Traumatic Scar Tissue Formation    

A new method for diagnosing susceptibility of post-traumatic scar tissue formation.



Our partner, University of Szeged has developed a PCR-based diagnostic kit with potential use in clinical practice. Based on their research, they identified a gene polymorphism which can be used as a diagnostic tool to reveal patients susceptible for post-traumatic scar tissue formation. The R&D phase of development is finished, preclinical phase has started. Our client is looking for partners interested in developing diagnostic kits.

Background information

Benign airway stenosis (BAS) is currently considered to be a multifactorial disorder in which, primarily, an injury to the tracheal mucosa and, additionally, the circumstances of intubation, general condition of the patient, microcirculation of the affected tracheal tissue layers, etc., serve as the key features in the pathogenesis of the disease.

Innovation and main advantages of the technology

The invention is a PCR-based method and a diagnostic kit for diagnosing post-traumatic scar tissue formation with the TGF-β1 gene-specific sequence. If the patient carries the homozygotic wild type allele of this gene, then the patient is considered to be susceptible to post-traumatic scar tissue formation.
The present invention is based on the surprising and unexpected finding that the ratio of the C/C genotype of -509 C/T TGF-β1 polymorphisms is higher among patients with post-traumatic tracheal scar tissue. Therefore, the determination of this polymorphism offers a good possibility to forecast susceptibility to the development of post-traumatic tracheal scar tissue.


- early stage diagnosis of post-traumatic tracheal scar tissue
- patient-friendly method
- opportunity for prophylaxis
- easy and simple way to diagnose accurately
- economical

Primary Application of the Technology

Diagnosing susceptibility for post-traumatic scar tissue formulation.

Potential areas of use: Pharmaceutical/Biotech industry; Clinics, hospitals (diagnostic applications)

The Problem Solved by the Technology

In some cases of endotracheal intubation benign airway stenosis can evolve. Respiration problems can cause nascent scar tissue, which must be eliminated by operation. We cannot forecast the post-traumatic scar tissue formation now, but our invention could resolve this problem.

Competitive Advantage

- early stage diagnosis of post-traumatic tracheal scar tissue
- patient-friendly method
- opportunity for prophylaxis
- easy and simple way to diagnose accurately
- economical

Additional Information

Stage of development: The research phase has been successfully closed, while the patenting process is in progress. The next step will be to enter the product development phase.

Type of collaboration: The client is interested in producers and/or product developers willing to acquire the patent rights through an in-license agreement.

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 435: Chemistry: Molecular Biology And Microbiology

This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.