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Patent for License:

Identification and utilization of antibacterial agents    

A technique of identifying the site of interaction between bacterial toxin and antitoxin polypeptides

Overview

The technology provides a method of identifying the site of interaction between bacterial toxin and antitoxin polypeptides. The technique includes

a) Exposing toxin and antitoxin polypeptides of a toxin-antitoxin pair produced by the bacterial cell to a plurality of molecules; and
b) Identifying a molecule of the plurality of molecules capable of preventing or disrupting binding between the antitoxin and the toxin polypeptides. It thus enables to identify or design antibiotics which target this site of interaction and thus enable bacterial cell killing.

The technology also provides a technique of treating an infection of bacteria by preventing or disrupting binding between a toxin and antitoxin polypeptides of a toxin-antitoxin pair produced in the bacteria.

The technology also provides a pharmaceutical composition for treating an infection of bacteria through an effective amount of an agent capable of preventing or disturbing binding between a toxin and antitoxin polypeptide.

Primary Application of the Technology

Pharmaceutical industry

The Problem Solved by the Technology

Several well-known antibiotics commonly used in healthcare have become ineffective as microbes develop resistance to them. The rate of mutation does not reciprocate with the discovery of antibiotics. Infectious microbes have a remarkable ability to evolve, adapt and develop drug resistance in an unpredictable and dynamic way. Antibiotic resistance first became challenging shortly after Penicillin gained extensive use in the 1940s.

Antibiotics currently being used against bacterial pathogens include beta-lactams (e.g., penicillin and cephalosporin) and glycopeptides (e.g., vancomycin and teichoplanin), which act to inhibit the final step in peptidoglycan synthesis, quinolones, which inhibit bacterial DNA replication, inhibitors of bacterial RNA polymerase such as rifampin, and aminoglycosides (e.g., kanamycin and gentamycin). Other well-known antibiotics include inhibitors of enzymes participating in production of tetrahydrofolate (e.g., sulfonamides).

How the Technology Solves the Problem

The limitation can be realized effectively with this novel technology which can be used for suppress the resistant strain incidence.

Comments on Deal Structure, Potential Terms and Restrictions

Technology available for Licensing; Buyer-side commission fee

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 435: Chemistry: Molecular Biology And Microbiology

This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.

Subclass 7.1: Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay