Patent for License:Identification and utilization of antibacterial agents
a) Exposing toxin and antitoxin polypeptides of a toxin-antitoxin pair produced by the bacterial cell to a plurality of molecules; and
b) Identifying a molecule of the plurality of molecules capable of preventing or disrupting binding between the antitoxin and the toxin polypeptides. It thus enables to identify or design antibiotics which target this site of interaction and thus enable bacterial cell killing.
The technology also provides a technique of treating an infection of bacteria by preventing or disrupting binding between a toxin and antitoxin polypeptides of a toxin-antitoxin pair produced in the bacteria.
The technology also provides a pharmaceutical composition for treating an infection of bacteria through an effective amount of an agent capable of preventing or disturbing binding between a toxin and antitoxin polypeptide.
Primary Application of the Technology
The Problem Solved by the Technology
Antibiotics currently being used against bacterial pathogens include beta-lactams (e.g., penicillin and cephalosporin) and glycopeptides (e.g., vancomycin and teichoplanin), which act to inhibit the final step in peptidoglycan synthesis, quinolones, which inhibit bacterial DNA replication, inhibitors of bacterial RNA polymerase such as rifampin, and aminoglycosides (e.g., kanamycin and gentamycin). Other well-known antibiotics include inhibitors of enzymes participating in production of tetrahydrofolate (e.g., sulfonamides).
How the Technology Solves the Problem
Comments on Deal Structure, Potential Terms and Restrictions
Class 435: Chemistry: Molecular Biology And Microbiology
This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.Subclass 7.1: Involving antigen-antibody binding, specific binding protein assay or specific ligand-receptor binding assay