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Inhibitors of Staphylococcus    

The technology is aimed at designing, synthesizing and recognizing potent inhibitors of SarA function, then using the inhibitors to treat staphylococcal infections.

Overview

Staphylococcus aureus (S. aureus), is responsible for infections such as skin abscesses to fatal conditions like pneumonia, endocarditis, septicemia, and toxic shock syndrome. Many patients who get S. aureus infections are resistant to many antibiotics. This medical invention offers a new approach to combate S. aureus that may bypass the organism's ability to develop resistance.

This technology approaches the treatment of staphylococcal virulence and infection in a different way – it interfers with the production of virulence factors, thus preventing the Staphylococcus species from becoming a potent pathogen. This means of treatment presents a way to attenuate staphylococcal virulence which is thought to be more broadly applicable than the Balaban inhibitor.

Primary Application of the Technology

Medical treatment

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 435: Chemistry: Molecular Biology And Microbiology

This class provides for the following subject matter when not provided for elsewhere: A process of using a microorganism or enzyme to synthesize a chemical product. A process of treating a material with a microorganism or enzyme to separate, liberate, or purify a preexisting substance. An in vitro process of measuring and testing in which: (1) A microorganism or enzyme is used to determine the presence or identity of a compound or composition in a sample; (2) A microorganism is identified by propagation; (3) An enzyme is identified by its catalytic activity; (4) The presence of microorganisms is detected; (5) A live microorganism is used in an antigen antibody test as an antigen; (6) Fixed or stabilized nonliving microorganisms, cells, or tissues are involved. A process of propagating a microorganism. A process in which the genetic structure of a microorganism or extrachromosomal genetic structure is altered. A process of organ or tissue maintenance. A process of mashing or malting. Microorganisms, per se, or the subcellular parts thereof. Enzymes, immobilized enzymes or enzyme containing compositions not otherwise provided for and the processes for purifying enzymes or forming immobilized enzymes. Compositions claimed or solely disclosed as for the propagation of microorganisms or for measuring and testing processes. Using microorganisms to destroy hazardous or toxic waste.

Subclass 6: Involving nucleic acid
Subclass 91.2: Acellular exponential or geometric amplification (e.g., PCR, etc.)

Class 536: Organic Compounds -- Part Of The Class 532 Series

The classes of the 532 series embrace monomeric organic carbon compounds and polymeric organic carbon compounds that are not solid synthetic resins, natural rubbers, or hydrocarbons.

Subclass 23.1: DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)
Subclass 24.1: Non-coding sequences which control transcription or translation processes (e.g., promoters, operators, enhancers, ribosome binding sites, etc.)
Subclass 24.5: Nucleic acid expression inhibitors