Thanks to their mild amphiphilic properties, this new derivatives can cross the cell membrane to release within the cell, following an enzymatic hydrolysis, GSH and corresponding polyunsaturated fatty acid both exerting protective activity against cell oxidative stress. The invention generally relates to lipophilic derivatives of glutathione and in particular S-acyl-glutathione derivatives usable as effective agents in counteracting the cytotoxic effects from prefibrillar protein aggregates, such as those found in the early phases of important degenerative diseases such as Alzheimer disease, Huntington chorea, etc. The invention also relates to a method for the synthesis of these derivatives and the pharmaceutical composition containing the derivatives.
Primary Application of the Technology
Potential industrial exploitation of this invention include the use of these novel GSH-derivatives as both dietary supplement or food integrator and/or as drugs in the pharma industry for the treatment of such diseases as Alzheimer, Huntington, Crohn.
European Patent Classes & Classifications Covered in this listing:
Class C07K5: CHEMISTRY; METALLURGY - ORGANIC CHEMISTRY
PEPTIDES . Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof .
Class A61K47: HUMAN NECESSITIES - MEDICAL OR VETERINARY SCIENCE; HYGIENE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES . Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives, .