Patent for License:

Patented material achieving anti-inflammatory effects    

Inhibition of cellular nitric oxide has anti-inflammatory and other beneficial effects


Chitosan and its derivatives can be used as an anti-inflammatory agent, especially for nitric oxide production. Nitric oxide (NO) is a highly reactive free radical and plays as an important second messenger molecule in many cell types. NO is synthesized from conversion of L-arginine to citrulline in vivo by nitric oxide synthase. In host defense system, activated macrophages by inflammatory agents such as interferon-g (IFN-g) and bacterial lipopolysaccharide (LPS) are known to produce a large quantity of NO as major cytotoxic mediator and inhibit the growth of invading microorganisms and tumor cells. However, this strong inflammatory response to foreign cells could also induce further damage for the neighboring cells and tissues around the wound area and thus, inhibit the healing process. There are reports that decreasing NO production by adding inhibitors of nitric oxide synthase and L-arginine analogues could protect some forms of injury. Wound healing is a complicated process including cell proliferation, migration and tissue reconstruction etc.. During the inflammation and infection, the attracted and activated macrophages produce a large amount of NO around the wound tissues (24, 32). NO has been proposed to be a major destructive factor in the wound healing process. This patent developed effect of chitin and its derivatives on NO production by the IFN-g and LPS activated RAW 264.7 macrophages. Our initial results indicated that chitin and chitosan significantly inhibited NO production by the activated

Primary Application of the Technology

The target market is functional foods, cosmetics, personal care products.

Other Potential Applications

Other applications include agriculture, health care, wound dressings.

Competitive Advantage

It is a natural product with mature production process. It can be used in different combinations.

Patent Summary

U.S. Patent Classes & Classifications Covered in this listing:

Class 514: Drug, Bio-Affecting And Body Treating Compositions

This class is an integral part of Class 424. It includes the following subject matter, not provided for elsewhere: 1. Drug and bio-affecting compositions which are capable of: preventing, alleviating, treating, or curing abnormal and pathological conditions of the living body; maintaining, increasing, decreasing, limiting, or destroying a physiologic body function; diagnosing a physiological condition or state by an in vivo test; controlling or protecting an environment or living body by attracting, disabling, inhibiting, killing, modifying, repelling or retarding an animal or micro-organism. 2. Body treating compositions generally intended for deodorizing, protecting, adorning, or grooming a body. 3. Fermentates. Plant and animal extracts, or body fluids or material containing plant or animal cellular structure. 4. Compositions of this class defined in terms of specific structure; e.g., layered tablet, capsule. 5. Processes of using or preparing subject matter of the Class Definition.

Subclass 55: Chitin or derivative
Subclass 61: Tri- or tetrasaccharide
Subclass 62: Glucosamine or derivative