Listing Status
- 2599
- , Currently available
-
- Exclusive license with right to enforce
- Exclusive license
- Non-exclusive license
- Region/country license
- Field-of-use license
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- 1 Patent Application - US
Patent for License with Right to Enforce:
Storage and Delivery of Nitric Oxide (NO) for HealingA method of storage and controlled delivery of Nitric Oxide for healing and organ preservation. A medical bandage, which releases Nitric Oxide to help heal wounds and improve blood circulation.
Overview
Invention:
The invention is a medical device, more specifically a bandage, which releases Nitric Oxide to help heal wounds, improve blood circulation and preserve organs being stored for transplant. The invention is unique Titanium dioxide nanotubes decorated with NO releasing groups to store and deliver NO using photochemical methods in both external and internal medical treatments.
Nitric Oxide opens blood vessels and keeps them relaxed, two of the key factors that help blood flow. Secondly this device inhibits thrombosis thereby preserving transplant organs. Though some recent efforts toward Nitric Oxide delivery have been concentrated on the fabrication of materials that release Nitric Oxide, this invention permits practitioners to control the discharge of this gas itself. This innate feature ensures that no harmful byproduct is formed as a result of the chemical interactions and gives more flexibility with the administration of the Nitric Oixde as per need.
It provides a method of storing NO that can be delivered to targeted spaces and a controlled photodynamic activation process that eliminates any potential by-product formation. This safe storage system can be combined with cream or lotion for topical treatments. The materials used in the fabrication of this delivery system are cheap and readily available and TiO2 nanotubes are produced in large quantities.
Background:
Time is the key factor in the organ transplantation process. A decrease of Nitric Oxide is an underlying reason for previously stored transplant organs to fail. The use of nitric oxide after cold storage of the donated organ may help maintain normal functioning after the transplant. More recently Nitric Oxide has also offered to help diabetic patients who suffer from lower blood flow in their extremities, especially in their feet. Though Nitric Oxide has defined benefits, the storage and controlled delivery of the Nitric Oxide gas itself has not been perfected.
The worldwide market for wound treatment adhesives and bandages is at $1.9 billion as of 2008, the North American market for the same is valued at 578.9 million. This sector is expected to grow at 8% percent based of on historical data. The worldwide market for solid organ transplant is estimated to be at $13 billion by 2013 with a sector growth rate of 5.7%. The total number of organs transplanted in the United States alone is increasing at 2-3 percent from 28,291 in 2006.
The diatomic free radical nitric oxide (NO) is an endogenous mediator of various physiological functions, including well documented applications in the gastrointestinal, genitourinary, cardiovascular, respiratory, and nervous systems. Through storage and delivery, medical practitioners have defined some useful therapeutic applications for NO as an antimicrobial agent, anticoagulant and cancer inhibitor. More recently NO has helped diabetic patients who suffer from lower blood flow. Another area of interest is the integration of NO releasing systems into tissue and organ preservation for transplant purposes.
Many chemical compounds have been developed to store and release NO in a controlled manner. In most compounds, the rate of NO release is varied through temperature, Ph or enzymes. Current technologies for the storage and controlled delivery of NO suffer from problems such as poor solubility, lack of specific targeting, generation of potentially toxic by-products and spontaneous NO release.
In the worldwide pharmaceutical market, share of drugs where NO is involved is projected to rise to $96 billion in 2010 as new drugs with NO-based mechanisms are introduced into the market.
The invention is a medical device, more specifically a bandage, which releases Nitric Oxide to help heal wounds, improve blood circulation and preserve organs being stored for transplant. The invention is unique Titanium dioxide nanotubes decorated with NO releasing groups to store and deliver NO using photochemical methods in both external and internal medical treatments.
Nitric Oxide opens blood vessels and keeps them relaxed, two of the key factors that help blood flow. Secondly this device inhibits thrombosis thereby preserving transplant organs. Though some recent efforts toward Nitric Oxide delivery have been concentrated on the fabrication of materials that release Nitric Oxide, this invention permits practitioners to control the discharge of this gas itself. This innate feature ensures that no harmful byproduct is formed as a result of the chemical interactions and gives more flexibility with the administration of the Nitric Oixde as per need.
It provides a method of storing NO that can be delivered to targeted spaces and a controlled photodynamic activation process that eliminates any potential by-product formation. This safe storage system can be combined with cream or lotion for topical treatments. The materials used in the fabrication of this delivery system are cheap and readily available and TiO2 nanotubes are produced in large quantities.
Background:
Time is the key factor in the organ transplantation process. A decrease of Nitric Oxide is an underlying reason for previously stored transplant organs to fail. The use of nitric oxide after cold storage of the donated organ may help maintain normal functioning after the transplant. More recently Nitric Oxide has also offered to help diabetic patients who suffer from lower blood flow in their extremities, especially in their feet. Though Nitric Oxide has defined benefits, the storage and controlled delivery of the Nitric Oxide gas itself has not been perfected.
The worldwide market for wound treatment adhesives and bandages is at $1.9 billion as of 2008, the North American market for the same is valued at 578.9 million. This sector is expected to grow at 8% percent based of on historical data. The worldwide market for solid organ transplant is estimated to be at $13 billion by 2013 with a sector growth rate of 5.7%. The total number of organs transplanted in the United States alone is increasing at 2-3 percent from 28,291 in 2006.
The diatomic free radical nitric oxide (NO) is an endogenous mediator of various physiological functions, including well documented applications in the gastrointestinal, genitourinary, cardiovascular, respiratory, and nervous systems. Through storage and delivery, medical practitioners have defined some useful therapeutic applications for NO as an antimicrobial agent, anticoagulant and cancer inhibitor. More recently NO has helped diabetic patients who suffer from lower blood flow. Another area of interest is the integration of NO releasing systems into tissue and organ preservation for transplant purposes.
Many chemical compounds have been developed to store and release NO in a controlled manner. In most compounds, the rate of NO release is varied through temperature, Ph or enzymes. Current technologies for the storage and controlled delivery of NO suffer from problems such as poor solubility, lack of specific targeting, generation of potentially toxic by-products and spontaneous NO release.
In the worldwide pharmaceutical market, share of drugs where NO is involved is projected to rise to $96 billion in 2010 as new drugs with NO-based mechanisms are introduced into the market.
Primary Application of the Technology
Wound healing/bandages
The Problem Solved by the Technology
Storage and controlled delivery of Nitric Oxide.
How the Technology Solves the Problem
See “Competitive Advantages” above.
Competitive Advantage
Large scale production is inexpensive and energy efficient
No dependency on Ph, humidity or temperature
Inside and outside surfaces can function separately
Creates no harmful byproduct
Increases time an organ can be in storage before transplanted
No dependency on Ph, humidity or temperature
Inside and outside surfaces can function separately
Creates no harmful byproduct
Increases time an organ can be in storage before transplanted
View this listing on the Tynax website: www.tynax.com/listing/2599